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  • The U.S. Food and Drug Administration has approved the usage of Contrave (naltrexone hydrochloride and bupropion hydrochloride extended-release tablets) to help manage chronic obesity in grown-ups with a body mass index (BMI) greater than 27, provided that they also experience weight-related medical issues such as Tupe2 diabestes, high cholesterol levels and/or hypertension (hypertension).Contrave can be a combination of two FDA-approved drugs, naltrexone and bupropion, in a extended-release formulation. Naltrexone is approved to treat alcohol and opioid dependence. Bupropion is eligible to treat depression and seasonal affective disorder in addition to being an aid to quitting smoking treatment.'Obesity continues to be a major public health concern,' said Jean-Marc Guettier, M.D., director in the Division of Metabolism and Endocrinology Products in FDA's Center for Drug Evaluation and Research. 'When used as directed in combination using a healthy lifestyle which includes a reduced-calorie exercise and dieting, Contrave provides another treatment selection for chronic weight reduction for people who are obese or are overweight and also have at least one weight-related health.'The drug's effectiveness was evaluated in multiple clinical trials that included approximately 4,500 obese and overweight patients with and without significant weight-related conditions treated for one year. All patients received lifestyle modification that contains a reduced- calorie diet and regular exercise. Results from a clinical study that enrolled patients without diabetes demonstrated that patients had an average weight loss of four years old.1% in contrast to participants who were given placebos) during a 12- month period, while a separate study involving patients with diabetes had a normal weight loss of 2% over treatment with placebo at one full year.

    Using two separate drugs to shed weight can be very effective you'll find combinations while watching FDA now awaiting approval. When dealing with weight reduction and the individuals who go through it you should err to the side of caution and permit the FDA do its job and demand some study be done in order that the public recognizes the side effects and risks of the medications before we bring them. Keep in mind that drug companies have been in business to make money and that they would say almost anything to keep people on the medications.

    Researchers discovered that participants taking this drug for the year, dropped a few pounds within 4 weeks and have kept the body weight off throughout the 56 weeks with the study. Contrave is really a combination with the drugs naltrexone and bupropion, which generally seems to reflect a new trend of weight-loss drugs which might be made up of multiple active ingredient, that might make them more potent and safer.

    Combo-pilling is the newest fad or better yet the newest to come under scrutiny and for that reason it is just more publicly known although in the past, comb-pilling for weight loss has been around since the eighties. The biggest reason that using a combination of pills has become popular is the fact that since right now there aren't long term prescription weight loss supplements that have been licensed by the FDA aside from orlistat. The truly disturbing part is that doctors are prescribing these combinations of medications even though some of the combinations have been rejected or have yet to be approved by the FDA.

    Seizures certainly are a side effect with Contrave and really should not be taken in people with seizure disorders. The drug also can raise blood pressure levels and heartbeat, and really should not be used in those with a history of heart attack or stroke in the previous six months. Blood pressure and pulse should also be measured before beginning the drug and throughout therapy with all the drug.

    The FDA also warned that Contrave can raise blood pressure and heart rate and must stop used in patients with uncontrolled high blood pressure levels, along with by a person with heart-related and cerebrovascular (blood vessel dysfunction impacting mental performance) disease. Patients using a history of cardiac arrest or stroke in the previous six months, life-threatening arrhythmias, or congestive heart failure were excluded in the clinical trials. Those taking Contrave must have their heart-rate and pulse monitored regularly. In addition, since the compound includes bupropion, Contrave comes using a boxed warning to alert medical researchers and patients for the increased likelihood of suicidal thoughts and behaviors connected with antidepressant drugs. The warning also notes that serious neuropsychiatric events happen to be reported in patients taking bupropion for smoking cessation.

    From a psychiatric standpoint, evidence shows that the ordinary neural mechanism for goal-directed behavior may be hijacked through the addiction, and malfunctions in a way that its ordinary functions are exaggerated and fixated on its object. An object produces a stimulus and also the person engages in a "goal-directed behavioral response" that generates a "natural high"(Bostwick & Bucci, 2008).