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  • The U.S. Food and Drug Administration has approved the application of Contrave (naltrexone hydrochloride and bupropion hydrochloride extended-release tablets) to assist manage chronic obesity in adults with a body mass index (BMI) in excess of 27, provided that they also have problems with weight-related health problems such as Tupe2 diabestes, high-cholesterol and/or hypertension (hypertension).Contrave can be a combination of two FDA-approved drugs, naltrexone and bupropion, in a extended-release formulation. Naltrexone qualifies to treat alcohol and opioid dependence. Bupropion qualifies to treat depression and seasonal affective disorder so when an aid to stopping smoking treatment.'Obesity is still a major public health concern,' said Jean-Marc Guettier, M.D., director from the Division of Metabolism and Endocrinology Products in FDA's Center for Drug Evaluation and Research. 'When used as directed in combination having a healthy lifestyle that includes a reduced-calorie exercise and dieting, Contrave provides another treatment selection for chronic weight loss for people who are obese or are overweight and possess at least one weight-related health problem.'The drug's effectiveness was evaluated in multiple numerous studies that included approximately 4,500 obese and overweight patients with and without significant weight-related conditions treated for just one year. All patients received lifestyle modification that contained a reduced- calorie diet and regular exercise. Results from a clinical trial that enrolled patients without diabetes showed that patients had a normal weight loss of four years old.1% in contrast to participants who have been given placebos) during a 12- month period, while a separate study involving patients with diabetes type 2 had the average weight loss of 2% over treatment with placebo at one year.

    Using two separate drugs to shed pounds can be very effective you will find combinations before the FDA now awaiting approval. When dealing with weight loss and the people that go through it you ought to err along the side of caution and allow FDA do its job and demand some investigation be done so the public recognizes the side effects and dangers of the medications before we bring them. Keep in mind that drug companies are in business to generate money and that they would say everything to keep people on the medications.

    Researchers found out that participants taking this drug for the year, lost weight within a month and have kept the body weight off through the 56 weeks with the study. Contrave is often a combination in the drugs naltrexone and bupropion, which appears to reflect a brand new trend of weight-loss drugs which can be made up of more than one active ingredient, which can make them far better and safer.

    Combo-pilling could be the newest fad or also the newest ahead under scrutiny and therefore it is just more publicly known recently, comb-pilling to lose weight has been around since the eighties. The biggest reason that employing a combination of pills is becoming popular may be the fact that at the time of right now there are no long term prescription diet pills that have been authorized by the FDA apart from orlistat. The truly disturbing part is doctors are prescribing these combinations of medications although some people might of the combinations are already rejected or have yet to be licensed by the FDA.

    Seizures certainly are a side effect with Contrave and really should not be taken in individuals with seizure disorders. The drug may also raise blood pressure level and pulse rate, and really should not be used in individuals with a history of cardiac event or stroke in the last six months. Blood pressure and pulse should also be measured before commencing the drug and throughout therapy using the drug.

    The FDA also warned that Contrave can raise blood pressure and heartbeat and must 't be used in patients with uncontrolled high blood pressure levels, and also by anyone with heart-related and cerebrovascular (blood vessel dysfunction impacting your brain) disease. Patients with a history of cardiac arrest or stroke in the earlier six months, life-threatening arrhythmias, or congestive heart failure were excluded through the clinical trials. Those taking Contrave really should have their heart-rate and pulse monitored regularly. In addition, considering that the compound includes bupropion, Contrave comes using a boxed warning to alert medical professionals and patients to the increased likelihood of suicidal thoughts and behaviors linked to antidepressant drugs. The warning also notes that serious neuropsychiatric events are actually reported in patients taking bupropion for stopping smoking.

    Most of the combinations which might be used to enhance weight-loss involve an amphetamine with an antidepressant. Phentermine and Prozac can be a popular combination that have been around for a long time, although it has been around no one wants to truly combine the two and try to get FDA approval to showcase it as a fat loss pill. Right there should raise some warning flag if the greedy pharmaceutical companies should not be involved in combining medications and selling them something has to be wrong while using combination. In fairness there exists one weight-loss combination pill which is in front of the FDA now Contrave?which couples naltrexone, accustomed to treat alcohol and drug addiction, with all the antidepressant bupropion (Wellbutrin, Zyban) it is often given the proceed to move forward by an FDA advisory committee, but at the time of yet will not be approved.